If you're running a medium to large pedalboard, then a buffer is definitely recommend. While True Bypass pedals are great, you also need something to drive the signal through the chain. Even using high quality cables in a large rig will never sound as good as 5ft of average cable plugged directly into an amp.
"The famous buffer that is in all Truetone pedals is also available in a tiny, Custom Shop package. Put it first in the chain of effects, plug in your input and output cables and a 9V power supply (like the 1 SPOT...), and your guitar will sound like it's plugged directly into your amp with a short cord. It's that simple, and yes, it really works. Completely eliminates cable capacitance and tone sucking."